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Gluten Sensitivity

The New England Journal of Medicine listed 55 "diseases" that can be caused by eating gluten.
N Engl J Med. 2002 Jan 17:346(3):180-8. Review, Huffington Post January 2, 2010.

If you would like accurate testing for Gluten Sensitivity, please call 414-761-5777 today and schedule with Dr. Ken Krimpelbein.


Celiac Disease

  • Celiac Disease is one of the most common lifelong disorders in both Europe and the US. (NEJM 348;25 June 19, 2003)
  • CD is a much greater problem than has previously been appreciated. [ARCH INTERN MED/VOL 163, Feb 2003]
  • In the past 7 years, 1 in 4 children were diagnosed as having Celiac Disease as a result of case-finding of associated conditions. [Pediatrics 2009; 124; 1572-1578]
  • CD diagnosed in childhood was associated with a 40% increase in suicide risk. [Dig Liver Dis 2011 Auf;43(8):616-22]
  • Autoimmune disorders occur 10 times more commonly in the Gluten Sensitive Enteropathy Celiac Disease than in the general population. [CMLS, Cell. Mol. Life Sci. 62 (2005) 791-799]
  • Prolonged fatigue, of "tired all the time" should alert the physician to CD. [Gastroenterol Hepatol 2003; 15: 407-13]
  • The incidence of CD increased five-fold from 1.3 per 100,000 in 1999 to 6.5 per 100,000 in 2008, with the highest rates of increase among those over 34 years of age. [Am J Gastroenterol. 2012 August:107(8):1248-55]
  • The latest numbers indicate that as many as one in every 5 people (yes, that's right) have some form of gluten-sensitivity. [Eur Rev Med Pharmacol Sci. 2010 Jun;14(6):567:72.]
  • The median increase in CV risk factors for Celiac is: myocardial infarction 18%, angina pectoris 35%, heart failure 26%, brain hemorrhage 46%, ischemic stroke 24% [Heart 2007;93:1111-1115]
  • The prevalence of CD in osteoporosis is high enough to justify a recommendation for serologic screening (blood tests) of all patients with osteoporosis for celiac disease. [ARCH INTERN MED/Vol. 165, Feb.28, 2005, 393-399]
  • 80% of patients not on the GFD had a low spine Bone Mineral Density. [J Bone Miner Res, 2004; 19:1112-1121]


Brain Health

  • Two female patients presented with cognitive decline that was attributed to Alzheimer dementia but ameliorated after the initiation of gluten-free diet. The third patient had peripheral neuropathy that completely resolved after the initiation of gluten-free diet. [J Clin Gastroenterol Vol. 42, No. 1, Jan. 2008.]
  • Gluten sensitivity should be considered as a state of heightened immunologic responsiveness to ingested gluten proteins in genetically predisposed individuals. The brain seems to be particularly vulnerable. [Pediatrics Vol. 108, No. 2, August 2001.]
  • In children and adolescents with silent CD (gluten sensitivity), we found a significant increase in disruptive behavioral and depressive disorders. [Scan. J. Gastro, 2005; 40:1407-1412.]
  • Patients with gluten-sensitive neuropathy show improvement on a gluten-free diet, while patients who continue to ingest gluten deteriorate further. [Clinical Neurology News, Vol. 2, No. 12, December 2006.]
  • Schizophrenia is frequently found in people with Celiac Disease and Celiac Disease is frequently found in people with schizophrenia. In cultures where gluten grains are rarely eaten, schizophrenia is rare or non-existent. [BMJ Volume 328, 21 February 2004.]
  • When the cause of a neurological disease is known, the percentage of those patients with elevated antibodies to gluten is 5%. When the cause of a neurological disease is unknown, the percentage of those patients with elevated antibodies to gluten is 57%. [J Neurol Neurosurg Psychiatry 2002;72:560-563.]
  • Gluten Sensitivity is a 'foundational' problem being recognized globally. [Non-Celiac Gluten Sensitivity', BMJ, 10, Dec, 2012]
  • The single most important risk factor for celiac disease is having a first-degree relative with already-defined celiac disease, particularly a sibling. A rate up to 20% or more has been noted. [World J Gastroenterol 2010 April 21; 16(15): 1828-1831]
  • All Celiac children clinically diagnosed with ADHD or their parents report a significant improvement in their behavior and functioning after 6 months on a gluten-free diet. [Journal of Attention Disorders, March 2006, 1-5]


Psoriasis

  • 34.1% of psoriasis patients have elevated antibodies to alpha-gliadin (AGA), a peptide of wheat. [Clinical and Experimental Dermatology, 36, 302-304, 2010.]
  • We found a highly significant correlation between positive serum AGA and duration of psoriasis. [Clinical and Experimental Dermatology, 36, 302-304, 2010.]
  • Recent studies showed an association between CD and psoriasis and an improvement of skin lesion after 3-6 months of gluten free diet.
  • Recent studies showed an association between CD and psoriasis and an improvement of skin lesion after 3-6 months of gluten free diet (GFD), without other pharmacological approaches.
  • Thirty of 33 patients with positive AGA antibodies strictly complied with GFD, and showed a significant decrease of psoriatic lesions. [World J Gastroenterol 2007; 13(14): 2138-2139.]
  • 16% of patients with psoriasis have been found to present high levels of anti-gluten antibodies. [J Intern Med 2011;269:582-590.]

Reflux

  • Celiac patients have a high prevalence of reflux esophagitis (19%). That a gluten free diet significantly decreased the relapse rate of gastro-oesophageal reflux disease (GORD) symptoms suggests that coelicac disease may represent a rish factor for development of reflux. [Gut 2003;52:514-517]
  • 39% of children with CD had esophagitis (30% of boys and 46% of girls with CD). [ISRN Gastroenterology Volume 2011, Article ID 489065]
  • The incidence of Eosinophilic Esophagitis in Celiac patients is increased compared with the general population. [J Clin Gastroenterol. 2012 Jan;46(1):e6-e11]
  • Gastroesophogeal Reflux Disease (GERD) symptoms are common in classically symptomatic untreated CD patients. The GFD is associated with a rapid and persistent improvement in reflux symptoms that resembles the healthy population. [Clin Gastroenterol Hepatol. 2011 Mar;9(3):214-9]

Downs Syndrome

  • A number of epidemiologic studies originating in countries such as Canada, Netherlands, Sweden, Italy, and Australia have recognized a prevalence of CD varying from 1% to 17% in individuals with Downs Syndrome. [Clin Pediatr (Phila). 2001 May;40(5):249-52.]
  • The prevalence of confirmed CD in our patients with DS is at least 96 times greater than the prevalence of CD in the general US pediatric population. [Clin Pediatr (Phila). 2001 May;40(5):249-52.]
  • Preliminary data from the United States reporting a prevalence rate of 4% to 5% CD in DS. [Acta Paediatr. 1999 Sep;88(9):953-6.]